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AP MSI MICROSATELLITE INSTABILITY (MSI) ANALYSIS by Idylla™

About This Test

Why is this test performed?

Microsatellite Instability (MSI) Analysis is performed to assess for defects in the DNA mismatch repair (MMR) system by detecting alterations in microsatellite length within microsatellite regions of the genome. MSI status serves as an important molecular biomarker in the evaluation of several solid tumours and may provide clinically relevant information for treatment planning.

MSI testing is commonly performed in patients with:

  • Colorectal carcinoma
  • Endometrial carcinoma
  • Gastric carcinoma
  • Ovarian carcinoma
  • Other selected solid tumours

Results should be interpreted in conjunction with histopathological findings, mismatch repair (MMR) protein testing, clinical history, and other relevant molecular investigations.

Overview

Test Name

MICROSATELLITE INSTABILITY (MSI) ANALYSIS by Idylla™

Test Code

AP MSI

Special Rate

Yes - Specialised

Test Schedule

3 working days

Turnaround Time

3 working days

Test Type

Single Test

Associated Cancer Types

Colorectal carcinoma, endometrial carcinoma, gastric carcinoma

Clinical Significance

MSI testing identifies tumors with deficient mismatch repair (dMMR) and is a predictive biomarker for response to immune checkpoint inhibitors.

Profile Component

Molecular

Specimen

Sample Requirement

2-3x 5µm FFPE Tissue with at least 30% tumour cellularity

FAQ

Q. What does MSI testing detect?

MSI testing detects instability within microsatellite regions of tumour DNA, which may indicate an underlying deficiency in DNA mismatch repair mechanisms.

Q. When should MSI testing be considered?

MSI testing may be considered in patients with selected solid tumours for tumour characterisation and assessment of potential mismatch repair deficiency.

Q. What specimen is required?

Testing is typically performed on formalin-fixed paraffin-embedded (FFPE) tumour tissue. Refer to laboratory specimen requirements for submission criteria.

Q. How should results be interpreted?

MSI results should be interpreted alongside clinical findings, histopathological assessment, and other relevant molecular or immunohistochemical investigations.

Lab Services Guide

Q. How can I get a copy of the Parkway Laboratory Services Guide?

Please contact us at 6278 9188 to request for a hard copy of the PLS Guide.

Ordering Test

Q. Can I add on an additional test after a blood sample has been taken?

This depends on the status of the sample. Please call us at 62789188 as soon as possible so that we can conduct the relevant checks on whether we can assist you with the request.

Q. Can test profiles be customised for my clinic?

Yes, if a profile you are looking for is not an existing profile listed in our laboratory services guide, please email pls.marketing@parkwaylabs.com.sg so that we can specially tailor profiles to cater to your needs.

Q. Do you have laboratory services after opening hours?

While we only accept samples during outpatient lab operating hours, samples continue to be processed after hours. For after hours inpatient specimens, samples will be sent through the Accident & Emergency department - additional charges will apply.

Consumable

Q. How do I request for consumables?

The fastest way is to make your request via Plexus. Alternatively, please call us at 62789188 to make your request.

Test Result

Q. I am a co-managing physician for one of my patients. Can my patient's test results be sent to me even though another physician ordered the test?

In order to safeguard confidentiality, test results will only be released directly to the physician who ordered the tests. However, we can also release results to co-managing physicians if the physician who ordered the tests makes an indication to do so in the lab request form.

Billing

Q. When are billing invoices usually issued?

Billing invoices are usually issued on the 2nd or the beginning of each month.

Q. Where should I mail my cheques to?

Please mail your cheques to the following:

Parkway Laboratory Services Ltd

c/o Parkway Hospitals Singapore Pte Ltd

Central Business Office

80 Bendemeer, #02-01

Singapore 339949

Attention: Central Business Office

Please ensure all cheques are crossed

  1. “A/C Payee only” and made payable to Parkway Laboratory Services Ltd.
  2. Please write your assigned customer number and invoice number on the reverse side of the cheque.
Q. Can payment be made at the outpatient lab?

For payment via credit card, please contact your account’s relevant Marketing representative to enquire. Alternatively, please email pls.marketing@parkwaylabs.com.sg

Please indicate the following information in your email:

Clinic Name,

Clinic Address,

Name of Person in charge,

Email address(es) to receive monthly PDF e-statements – you may include email address(es) to be copied too.

Q. Can I make payment via credit card?

Yes, you may make payment via credit card. Please approach one of our friendly client service representatives at any one of our outpatient laboratories to make payment via credit card.

Why is this test performed?

Microsatellite Instability (MSI) Analysis is performed to assess for defects in the DNA mismatch repair (MMR) system by detecting alterations in microsatellite length within microsatellite regions of the genome. MSI status serves as an important molecular biomarker in the evaluation of several solid tumours and may provide clinically relevant information for treatment planning.

MSI testing is commonly performed in patients with:

  • Colorectal carcinoma
  • Endometrial carcinoma
  • Gastric carcinoma
  • Ovarian carcinoma
  • Other selected solid tumours

Results should be interpreted in conjunction with histopathological findings, mismatch repair (MMR) protein testing, clinical history, and other relevant molecular investigations.

Test Name

MICROSATELLITE INSTABILITY (MSI) ANALYSIS by Idylla™

Test Code

AP MSI

Special Rate

Yes - Specialised

Test Schedule

3 working days

Turnaround Time

3 working days

Test Type

Single Test

Colorectal carcinoma, endometrial carcinoma, gastric carcinoma

MSI testing identifies tumors with deficient mismatch repair (dMMR) and is a predictive biomarker for response to immune checkpoint inhibitors.

Molecular

Sample Requirement

2-3x 5µm FFPE Tissue with at least 30% tumour cellularity

Q. What does MSI testing detect?

MSI testing detects instability within microsatellite regions of tumour DNA, which may indicate an underlying deficiency in DNA mismatch repair mechanisms.

Q. When should MSI testing be considered?

MSI testing may be considered in patients with selected solid tumours for tumour characterisation and assessment of potential mismatch repair deficiency.

Q. What specimen is required?

Testing is typically performed on formalin-fixed paraffin-embedded (FFPE) tumour tissue. Refer to laboratory specimen requirements for submission criteria.

Q. How should results be interpreted?

MSI results should be interpreted alongside clinical findings, histopathological assessment, and other relevant molecular or immunohistochemical investigations.

Lab Services Guide

Q. How can I get a copy of the Parkway Laboratory Services Guide?

Please contact us at 6278 9188 to request for a hard copy of the PLS Guide.

Ordering Test

Q. Can I add on an additional test after a blood sample has been taken?

This depends on the status of the sample. Please call us at 62789188 as soon as possible so that we can conduct the relevant checks on whether we can assist you with the request.

Q. Can test profiles be customised for my clinic?

Yes, if a profile you are looking for is not an existing profile listed in our laboratory services guide, please email pls.marketing@parkwaylabs.com.sg so that we can specially tailor profiles to cater to your needs.

Q. Do you have laboratory services after opening hours?

While we only accept samples during outpatient lab operating hours, samples continue to be processed after hours. For after hours inpatient specimens, samples will be sent through the Accident & Emergency department - additional charges will apply.

Consumable

Q. How do I request for consumables?

The fastest way is to make your request via Plexus. Alternatively, please call us at 62789188 to make your request.

Test Result

Q. I am a co-managing physician for one of my patients. Can my patient's test results be sent to me even though another physician ordered the test?

In order to safeguard confidentiality, test results will only be released directly to the physician who ordered the tests. However, we can also release results to co-managing physicians if the physician who ordered the tests makes an indication to do so in the lab request form.

Billing

Q. When are billing invoices usually issued?

Billing invoices are usually issued on the 2nd or the beginning of each month.

Q. Where should I mail my cheques to?

Please mail your cheques to the following:

Parkway Laboratory Services Ltd

c/o Parkway Hospitals Singapore Pte Ltd

Central Business Office

80 Bendemeer, #02-01

Singapore 339949

Attention: Central Business Office

Please ensure all cheques are crossed

  1. “A/C Payee only” and made payable to Parkway Laboratory Services Ltd.
  2. Please write your assigned customer number and invoice number on the reverse side of the cheque.
Q. Can payment be made at the outpatient lab?

For payment via credit card, please contact your account’s relevant Marketing representative to enquire. Alternatively, please email pls.marketing@parkwaylabs.com.sg

Please indicate the following information in your email:

Clinic Name,

Clinic Address,

Name of Person in charge,

Email address(es) to receive monthly PDF e-statements – you may include email address(es) to be copied too.

Q. Can I make payment via credit card?

Yes, you may make payment via credit card. Please approach one of our friendly client service representatives at any one of our outpatient laboratories to make payment via credit card.



Specimen Collection Request Form

Please complete the form to make a request

Example: 20M0163, Click here to go to HCI Website
Unable to retrieve clinic information, please contact PLS hotline at 65-62789188.
Clinic Staff Name

About This Test

Why is this test performed?

Microsatellite Instability (MSI) Analysis is a test used to look for changes in the way tumour cells repair damaged DNA. When the body's natural DNA repair system is not working properly, errors can build up in the genetic material of cancer cells, leading to a condition known as microsatellite instability (MSI).

Your doctor may recommend MSI testing if you have been diagnosed with, or are being evaluated for, certain cancers, including:

  • Colorectal cancer
  • Endometrial (uterine) cancer
  • Stomach cancer
  • Ovarian cancer
  • Other selected cancers

The results can provide additional information about the genomic profile of a tumour and may help guide further investigations or treatment planning.

Overview

Test Name

MICROSATELLITE INSTABILITY (MSI) ANALYSIS by Idylla™

Test Code

AP MSI

FAQ

Q. What is microsatellite instability (MSI)?

Microsatellites are short repeated sections of DNA. When the body's DNA repair system is not functioning properly, changes can occur in these regions, resulting in microsatellite instability.

Q. Why has my doctor requested this test?

Your doctor may request MSI testing to better understand the genetic characteristics of a tumour and obtain information that may support treatment planning.

Q. What sample is needed?

The test is usually performed on a tumour tissue sample collected during a biopsy or surgery.

Q. What do the results mean?

The results indicate whether microsatellite instability is present in the tumour. Your doctor will explain how the findings relate to your specific condition and any further investigations or treatment considerations.

Taking a Tests

Q. Can I walk into the outpatient lab for a blood test?

If you have consulted a doctor and the clinic has provided you with a completed laboratory request form, you may visit our outpatient labs for a blood test. Patients must produce the completed laboratory request form in order for us to proceed with the doctor's orders.

If you have not consulted a doctor, please do so. As blood test results are best interpreted with clinical findings and family history, you should seek a doctor’s advice so relevant tests for your condition are appropriately analysed. Besides visiting your family physician or specialist, you may wish to have the tests done at any of our Parkway Shenton Medical Group clinics located island wide. Or you may also opt to have tests done at Executive Health Screeners, located within our hospital premises.

After your consultation with the doctor, the clinic will assist to complete a laboratory request form and you may have your blood samples drawn either at the clinic or at one of our outpatient laboratories.

Q. How long must I fast if required?

If the tests you are doing require fasting, you should fast for at least 12 hours after a normal meal.

Q. Can I drink while fasting?

You can drink plain water during the fasting period

Q. Where can I go for my blood to be drawn?

You may visit us at any of our outpatient laboratories during office hours with a Laboratory Request Form signed by your doctor.

Test Result

Q. Where can I get my laboratory report after a blood screening?

Your laboratory report will be sent to your doctor when completed.

Q. Can test results be sent to me directly?

Test results will only be released directly to the physician who ordered the tests. This is because test results need to be reviewed in consultation with a physician for an in depth explanation and interpretation of your results.

Q. Who should explain to me about my laboratory results?

Laboratory results should only be interpreted together with clinical findings and family history, therefore your doctor is the best person to interpret your laboratory results.

Q. How soon can I get my results?

Different tests have different turnaround time for the completion of the tests. It can range between an hour to 14 days. Please check with your doctor.

Payment

Q. My doctor has asked me to pay for my blood tests at the laboratory. What mode of payment do you accept?

We accept cash, major credit cards and NETS.

Why is this test performed?

Microsatellite Instability (MSI) Analysis is a test used to look for changes in the way tumour cells repair damaged DNA. When the body's natural DNA repair system is not working properly, errors can build up in the genetic material of cancer cells, leading to a condition known as microsatellite instability (MSI).

Your doctor may recommend MSI testing if you have been diagnosed with, or are being evaluated for, certain cancers, including:

  • Colorectal cancer
  • Endometrial (uterine) cancer
  • Stomach cancer
  • Ovarian cancer
  • Other selected cancers

The results can provide additional information about the genomic profile of a tumour and may help guide further investigations or treatment planning.

Test Name

MICROSATELLITE INSTABILITY (MSI) ANALYSIS by Idylla™

Test Code

AP MSI

Q. What is microsatellite instability (MSI)?

Microsatellites are short repeated sections of DNA. When the body's DNA repair system is not functioning properly, changes can occur in these regions, resulting in microsatellite instability.

Q. Why has my doctor requested this test?

Your doctor may request MSI testing to better understand the genetic characteristics of a tumour and obtain information that may support treatment planning.

Q. What sample is needed?

The test is usually performed on a tumour tissue sample collected during a biopsy or surgery.

Q. What do the results mean?

The results indicate whether microsatellite instability is present in the tumour. Your doctor will explain how the findings relate to your specific condition and any further investigations or treatment considerations.

Taking a Tests

Q. Can I walk into the outpatient lab for a blood test?

If you have consulted a doctor and the clinic has provided you with a completed laboratory request form, you may visit our outpatient labs for a blood test. Patients must produce the completed laboratory request form in order for us to proceed with the doctor's orders.

If you have not consulted a doctor, please do so. As blood test results are best interpreted with clinical findings and family history, you should seek a doctor’s advice so relevant tests for your condition are appropriately analysed. Besides visiting your family physician or specialist, you may wish to have the tests done at any of our Parkway Shenton Medical Group clinics located island wide. Or you may also opt to have tests done at Executive Health Screeners, located within our hospital premises.

After your consultation with the doctor, the clinic will assist to complete a laboratory request form and you may have your blood samples drawn either at the clinic or at one of our outpatient laboratories.

Q. How long must I fast if required?

If the tests you are doing require fasting, you should fast for at least 12 hours after a normal meal.

Q. Can I drink while fasting?

You can drink plain water during the fasting period

Q. Where can I go for my blood to be drawn?

You may visit us at any of our outpatient laboratories during office hours with a Laboratory Request Form signed by your doctor.

Test Result

Q. Where can I get my laboratory report after a blood screening?

Your laboratory report will be sent to your doctor when completed.

Q. Can test results be sent to me directly?

Test results will only be released directly to the physician who ordered the tests. This is because test results need to be reviewed in consultation with a physician for an in depth explanation and interpretation of your results.

Q. Who should explain to me about my laboratory results?

Laboratory results should only be interpreted together with clinical findings and family history, therefore your doctor is the best person to interpret your laboratory results.

Q. How soon can I get my results?

Different tests have different turnaround time for the completion of the tests. It can range between an hour to 14 days. Please check with your doctor.

Payment

Q. My doctor has asked me to pay for my blood tests at the laboratory. What mode of payment do you accept?

We accept cash, major credit cards and NETS.

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